Examples

nTerim Application Example
2 means example using the Pocock Spending Function
A study is being carried out to compare two-year survival after surgery for a brain tumour for patients treated with a new combination of chemotherapy and radiation….Read More

Calculating Sample Size for Proportions with more than 2 groups
Test for linear trend in G x 2 table (logistic model)(PGT1)
nQuery Advisor provides sample size computations for a logistic model when the
response variable is yes/no and the covariate is a discrete ordered variable such as
fixed dose levels….Read More

nQuery Advisor Tutorial with Japanese Translation
A fully worked example
Showing all aspects of nQuery Advisor, including statements, plots, etc. Download PDF

Creating a Randomization List for a Simple Study
For assigning subjects to groups
This option is for simple designs with 2 to 20 treatments/groups to which subjects must be assigned. Use this option if: …Read More

Complex Design Randomization
This option is for complex designs with multiple treatments, groups, centers and stratifying factors…Read More

Epidemiology Example
Sample Size for Confidence interval for odds ratio
What sample size is required for an experiment to estimate an odds ratio with a confidence interval of specified width?…Read More

Oncology Example
Sample Size for survival analysis
What sample size is required for a study to have 90% power for a comparison of two year survival after surgery for a brain tumor for patients treated with a new combination of chemotherapy and radiation versus those treated with standard methods?…Read More

Second Oncology Example
Sample Size for non-inferiority for survival studies
Many cancer drugs although effective in prolonging survival put patients at considerable risk for serious adverse events. A new drug with an improved safety profile would be of interest even if it did not increase survival as long as survival was not decreased…Read More

Genetics Example
Sample Size for Analysis of Variance with unequal n’s
Does a candidate gene influence impaired glucose tolerance in a specified population thought to be susceptible to diabetes?…Read More

Pharmacology Example
Sample Size for Contrast in ANOVA
What sample size is required for an experiment to determine the nature of a dose response to a new drug?…Read More

Psychology Example
Sample Size for Two-way ANOVA
What sample size is required for an experiment in which the effects on a dependent learning variable of age at two levels, nature of contingency reinforcement at four levels and their interaction will be studied?…Read More

Bioequivalence Example
Sample Size for TOST for means-crossover
What sample size is required for a 2×2 crossover study to have 90% power for establishment of equivalence between the 32 hour AUC of two different dosage forms of a drug?…Read More

Dental Research Example
Sample Size for Equivalence of Proportions
What sample size is required for a study comparing a new type of dental implant to a reference standard?…Read More